Ischaemic brain damage in the gerbil in the absence of 'no-reflow'.
نویسندگان
چکیده
Approximately 40% of gerbils subjected to one hour of unilateral carotid artery occlusion displayed neurological abnormalities during that time. Most such animals were subsequently found to have ischaemic neuronal alterations within the territory of the ipsilateral middle cerebral artery. In contrast, impaired reperfusion ('no-reflow') rarely occurred and cannot therefore be implicated in the pathogenesis of ischaemic brain damage.
منابع مشابه
Ischaemic brain damage in the gerbil in the absence of 'no-reflow'1
Ames and his co-workers (Ames et al., 1968; Cantu et al., 1969) observed in rabbits that periods of cerebral ischaemia (circulatory arrest) of more than five minutes were followed by multifocal deficits in brain reperfusion as assessed by the post-ischaemic, intra-arterial injection of a suspension of carbon black. These zones of non-perfusion increased in number and size with increasing length...
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The no-reflow phenomenon has been produced in the cerebral hemispheres of the gerbil by 30 minutes of bilateral carotid artery occlusion. The no-reflow phenomenon was found to develop in relation to the fall in blood pressure which occurred on release of bilateral carotid clips. Metaraminol tartrate intravenously prevented the fall of blood pressure and significantly reduced the occurrence of t...
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ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 38 12 شماره
صفحات -
تاریخ انتشار 1975